Related Research
Learn more about our studies
Brain Health
Interested in being a research participant?
Please contact our Geras Research Coordinator at (905) 521-2100 ext.77866 for more information.
Overview: This study will test whether taking a special supplement (ketone monoester) every day for 14 days can help improve brain blood flow, brain activity, and memory or thinking skills in middle-aged and older adults who have early memory concerns, compared to people taking a placebo.
| Study Type: | Interventional |
| Overview & Objectives: | There is an urgent need for interventions which reduce dementia risk in aging adults. People with subjective cognitive decline (SCD) have a greater risk of developing dementia compared to age-matched cognitively normal individuals. Impaired cerebral blood flow (CBF) and cerebral glucose hypometabolism are leading mechanisms underlying dementia that could be ideal interventional targets for this population. Recent research including our own work has shown that oral consumption of ketone monoesters (KME) can improve CBF and cerebral metabolism, which in turn can improve cognition. The purpose of this study is to investigate the hypothesis that, a 14-day KME supplementation intervention in middle-to-older adults with SCD will increase CBF, brain functional connectivity, and cognitive performance in comparison to placebo. |
| Methods: |
A total of 34 middle-to-older adults with subjective cognitive decline. Participants will complete study visits immediately before and after 14 days of thrice-daily supplementation with a ketone monoester (KME) or a placebo. Following a minimum 14-day washout period, participants will repeat the protocol to complete study visits immediately before and after 14 days of thrice-daily supplementation with the other intervention (KME or placebo). |
