Assessing Muscle Quality in Post-Menopausal Women With Type 2 Diabetes Using MRI

Aim: To determine (1) whether intramuscular adipose tissue (IntraMAT) differs between women with and without type 2 Diabetes using MRI.

Overview: 59 women ≥ 65 years with and without type 2 diabetes participated in the study.

Measurement components:

  • Magnetic Resonance Imaging (MRI)
  • Dual X-ray Absorptiometry (DXA)
  • Grip strength
  • Timed up and go
  • ​Physical activity questionnaire

Results: Women with diabetes had more IntraMAT. After adjustment, IntraMAT was similar between groups. IntraMAT was related to TUG and grip strength, but the relationships became non-significant after adjustment for covariates. IntraMAT alone may not be a clinically important predictor of functional mobility and strength; however, whether losses in functional mobility and strength are promoted by IntraMAT accumulation should be explored.

Components of Success:

  • Development of MRI segmentation technique
  • Enhances understanding of adipose tissue infiltration into skeletal muscle and the implications on mobility and strength