Aim: To determine (1) whether intramuscular adipose tissue (IntraMAT) differs between women with and without type 2 Diabetes using MRI.
Overview: 59 women ≥ 65 years with and without type 2 diabetes participated in the study.
- Magnetic Resonance Imaging (MRI)
- Dual X-ray Absorptiometry (DXA)
- Grip strength
- Timed up and go
- Physical activity questionnaire
Results: Women with diabetes had more IntraMAT. After adjustment, IntraMAT was similar between groups. IntraMAT was related to TUG and grip strength, but the relationships became non-significant after adjustment for covariates. IntraMAT alone may not be a clinically important predictor of functional mobility and strength; however, whether losses in functional mobility and strength are promoted by IntraMAT accumulation should be explored.
Components of Success:
- Development of MRI segmentation technique
- Enhances understanding of adipose tissue infiltration into skeletal muscle and the implications on mobility and strength