On behalf of all co-investigators, Dr. Gajic-Veljanoski, GERAS Post-Doctoral Fellow(second from the left), supported by the HHS Foundation, presented research related to the effects of osteoporotic fractures on frailty progression at this year’s ASBMR meeting in Atlanta, USA. The study examined changes in rates of frailty over 10 years in a CaMos cohort of women and men aged 50 years and older.
It was found that incident clinical vertebral fractures, in addition to hip fractures, significantly accelerated the progression of frailty, after adjusting for prior fractures and other risk factors for frailty or osteoporosis. The effects of fractures on frailty progression differed between women and men who had no history of fracture. In women without prevalent fractures, a new clinical vertebral fracture had a similar impact as an incident hip fracture. In men without prior fractures, an incident hip fracture had the largest impact on an increase in frailty as compared to incident vertebral or non-hip-non-vertebral fractures.
This research suggests that early prevention of vertebral and hip fractures in older women and men can alleviate the burden of frailty and potentially benefit long-term outcomes such as survival and quality of life. For this research, Dr. Gajic-Veljanoski et al. received a Plenary Poster Award and a ASBMR Young Investigator Travel Award.
O Gajic-Veljanoski, JD Adachi, C Kennedy, G Ioannidis, C Berger, A Kin On Wong, K Rockwood, S Kirkland, P Raina, L Thabane, A Papaioannou, and the CaMos Research Group. Vertebral fractures have similar impact as hip fractures on the progression of frailty. ASBMR, Sep 14-18, 2016, Atlanta, USA.